{"item_id": "SYN-01", "split": "dev", "text": "FICTIONAL TRAINING EXCERPT SYN-01. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 70 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nAfter screening 87 candidates, 60 participants were randomized.\nAllocation assigned 30 participants to the intervention and 30 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nThe primary endpoint visit was at 8 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -1 mmHg in the control group.\nSupplement: 54 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "60", "intervention_n": "30", "control_n": "30", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-3", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 87 candidates, 60 participants were randomized.", "intervention_n": "Allocation assigned 30 participants to the intervention and 30 to usual care.", "control_n": "Allocation assigned 30 participants to the intervention and 30 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-02", "split": "dev", "text": "FICTIONAL TRAINING EXCERPT SYN-02. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 78 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 95 candidates, 68 participants were randomized.\nAllocation assigned 34 participants to the intervention and 34 to usual care.\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nSupplement: 62 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "68", "intervention_n": "34", "control_n": "34", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-4", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 95 candidates, 68 participants were randomized.", "intervention_n": "Allocation assigned 34 participants to the intervention and 34 to usual care.", "control_n": "Allocation assigned 34 participants to the intervention and 34 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-03", "split": "dev", "text": "FICTIONAL TRAINING EXCERPT SYN-03. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 86 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe study took place in India.\nAfter screening 103 candidates, 76 participants were randomized.\nAllocation assigned 38 participants to the intervention and 38 to usual care.\nThe intervention was a home exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nSupplement: 70 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "76", "intervention_n": "38", "control_n": "38", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-5", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 103 candidates, 76 participants were randomized.", "intervention_n": "Allocation assigned 38 participants to the intervention and 38 to usual care.", "control_n": "Allocation assigned 38 participants to the intervention and 38 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-04", "split": "dev", "text": "FICTIONAL TRAINING EXCERPT SYN-04. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 94 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAfter screening 111 candidates, 84 participants were randomized.\nAllocation assigned 42 participants to the intervention and 42 to usual care.\nThe intervention was a group exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nSupplement: 78 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "84", "intervention_n": "42", "control_n": "42", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-6", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 111 candidates, 84 participants were randomized.", "intervention_n": "Allocation assigned 42 participants to the intervention and 42 to usual care.", "control_n": "Allocation assigned 42 participants to the intervention and 42 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-05", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-05. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 102 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAllocation assigned 46 participants to the intervention and 46 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nThe primary endpoint visit was at 8 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nAfter screening 119 candidates, 92 participants were randomized.\nSupplement: 86 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "92", "intervention_n": "46", "control_n": "46", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-7", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 119 candidates, 92 participants were randomized.", "intervention_n": "Allocation assigned 46 participants to the intervention and 46 to usual care.", "control_n": "Allocation assigned 46 participants to the intervention and 46 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-06", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-06. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 110 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 127 candidates, 100 participants were randomized.\nAllocation assigned 50 participants to the intervention and 50 to usual care.\nSupplement: 94 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "100", "intervention_n": "50", "control_n": "50", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-8", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 127 candidates, 100 participants were randomized.", "intervention_n": "Allocation assigned 50 participants to the intervention and 50 to usual care.", "control_n": "Allocation assigned 50 participants to the intervention and 50 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-07", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-07. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 118 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in India.\nAfter screening 135 candidates, 108 participants were randomized.\nAllocation assigned 54 participants to the intervention and 54 to usual care.\nThe intervention was a home exercise.\nSupplement: 102 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "108", "intervention_n": "54", "control_n": "54", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-9", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 135 candidates, 108 participants were randomized.", "intervention_n": "Allocation assigned 54 participants to the intervention and 54 to usual care.", "control_n": "Allocation assigned 54 participants to the intervention and 54 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-08", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-08. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 126 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nAfter screening 143 candidates, 116 participants were randomized.\nAllocation assigned 58 participants to the intervention and 58 to usual care.\nThe intervention was a group exercise.\nThe comparator was usual care.\nSupplement: 110 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "116", "intervention_n": "58", "control_n": "58", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-10", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 143 candidates, 116 participants were randomized.", "intervention_n": "Allocation assigned 58 participants to the intervention and 58 to usual care.", "control_n": "Allocation assigned 58 participants to the intervention and 58 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-09", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-09. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 134 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nAfter screening 151 candidates, 124 participants were randomized.\nAllocation assigned 62 participants to the intervention and 62 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nThe primary endpoint visit was at 8 weeks.\nSupplement: 118 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "124", "intervention_n": "62", "control_n": "62", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-3", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 151 candidates, 124 participants were randomized.", "intervention_n": "Allocation assigned 62 participants to the intervention and 62 to usual care.", "control_n": "Allocation assigned 62 participants to the intervention and 62 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-10", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-10. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 142 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 159 candidates, 132 participants were randomized.\nAllocation assigned 66 participants to the intervention and 66 to usual care.\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nSupplement: 126 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "132", "intervention_n": "66", "control_n": "66", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-4", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 159 candidates, 132 participants were randomized.", "intervention_n": "Allocation assigned 66 participants to the intervention and 66 to usual care.", "control_n": "Allocation assigned 66 participants to the intervention and 66 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-11", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-11. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 150 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in India.\nAfter screening 167 candidates, 140 participants were randomized.\nAllocation assigned 70 participants to the intervention and 70 to usual care.\nThe intervention was a home exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nSupplement: 134 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "140", "intervention_n": "70", "control_n": "70", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-5", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 167 candidates, 140 participants were randomized.", "intervention_n": "Allocation assigned 70 participants to the intervention and 70 to usual care.", "control_n": "Allocation assigned 70 participants to the intervention and 70 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-12", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-12. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 158 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAt the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nAfter screening 175 candidates, 148 participants were randomized.\nAllocation assigned 74 participants to the intervention and 74 to usual care.\nThe intervention was a group exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nSupplement: 142 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "148", "intervention_n": "74", "control_n": "74", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-6", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 175 candidates, 148 participants were randomized.", "intervention_n": "Allocation assigned 74 participants to the intervention and 74 to usual care.", "control_n": "Allocation assigned 74 participants to the intervention and 74 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-13", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-13. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 166 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nAfter screening 183 candidates, 156 participants were randomized.\nAllocation assigned 78 participants to the intervention and 78 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nThe primary endpoint visit was at 8 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -1 mmHg in the control group.\nSupplement: 150 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "156", "intervention_n": "78", "control_n": "78", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-7", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 183 candidates, 156 participants were randomized.", "intervention_n": "Allocation assigned 78 participants to the intervention and 78 to usual care.", "control_n": "Allocation assigned 78 participants to the intervention and 78 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-14", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-14. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 174 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 191 candidates, 164 participants were randomized.\nAllocation assigned 82 participants to the intervention and 82 to usual care.\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nSupplement: 158 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "164", "intervention_n": "82", "control_n": "82", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-8", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 191 candidates, 164 participants were randomized.", "intervention_n": "Allocation assigned 82 participants to the intervention and 82 to usual care.", "control_n": "Allocation assigned 82 participants to the intervention and 82 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-15", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-15. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 182 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nEligible participants were adults with essential hypertension.\nThe study took place in India.\nAfter screening 199 candidates, 172 participants were randomized.\nAllocation assigned 86 participants to the intervention and 86 to usual care.\nThe intervention was a home exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nSupplement: 166 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "172", "intervention_n": "86", "control_n": "86", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-9", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 199 candidates, 172 participants were randomized.", "intervention_n": "Allocation assigned 86 participants to the intervention and 86 to usual care.", "control_n": "Allocation assigned 86 participants to the intervention and 86 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-16", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-16. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 190 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAfter screening 207 candidates, 180 participants were randomized.\nAllocation assigned 90 participants to the intervention and 90 to usual care.\nThe intervention was a group exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nSupplement: 174 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "180", "intervention_n": "90", "control_n": "90", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-10", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 207 candidates, 180 participants were randomized.", "intervention_n": "Allocation assigned 90 participants to the intervention and 90 to usual care.", "control_n": "Allocation assigned 90 participants to the intervention and 90 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-17", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-17. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 198 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAfter screening 215 candidates, 188 participants were randomized.\nAllocation assigned 94 participants to the intervention and 94 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nThe primary endpoint visit was at 8 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nSupplement: 182 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "188", "intervention_n": "94", "control_n": "94", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-3", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 215 candidates, 188 participants were randomized.", "intervention_n": "Allocation assigned 94 participants to the intervention and 94 to usual care.", "control_n": "Allocation assigned 94 participants to the intervention and 94 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -3 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-18", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-18. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 206 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nAllocation assigned 98 participants to the intervention and 98 to usual care.\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 223 candidates, 196 participants were randomized.\nSupplement: 190 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "196", "intervention_n": "98", "control_n": "98", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-4", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 223 candidates, 196 participants were randomized.", "intervention_n": "Allocation assigned 98 participants to the intervention and 98 to usual care.", "control_n": "Allocation assigned 98 participants to the intervention and 98 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -4 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-19", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-19. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 214 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in India.\nAfter screening 231 candidates, 204 participants were randomized.\nAllocation assigned 102 participants to the intervention and 102 to usual care.\nThe intervention was a home exercise.\nSupplement: 198 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "204", "intervention_n": "102", "control_n": "102", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-5", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 231 candidates, 204 participants were randomized.", "intervention_n": "Allocation assigned 102 participants to the intervention and 102 to usual care.", "control_n": "Allocation assigned 102 participants to the intervention and 102 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -5 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-20", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-20. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 222 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe comparator was usual care.\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nAfter screening 239 candidates, 212 participants were randomized.\nAllocation assigned 106 participants to the intervention and 106 to usual care.\nThe intervention was a group exercise.\nSupplement: 206 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "212", "intervention_n": "106", "control_n": "106", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-6", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 239 candidates, 212 participants were randomized.", "intervention_n": "Allocation assigned 106 participants to the intervention and 106 to usual care.", "control_n": "Allocation assigned 106 participants to the intervention and 106 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -6 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-21", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-21. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 230 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe primary endpoint visit was at 8 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Canada.\nAfter screening 247 candidates, 220 participants were randomized.\nAllocation assigned 110 participants to the intervention and 110 to usual care.\nThe intervention was a walking program.\nThe comparator was usual care.\nSupplement: 214 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Canada", "randomized_total": "220", "intervention_n": "110", "control_n": "110", "intervention": "walking program", "comparator": "usual care", "duration_weeks": "8", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-7", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Canada.", "randomized_total": "After screening 247 candidates, 220 participants were randomized.", "intervention_n": "Allocation assigned 110 participants to the intervention and 110 to usual care.", "control_n": "Allocation assigned 110 participants to the intervention and 110 to usual care.", "intervention": "The intervention was a walking program.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 8 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -7 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-22", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-22. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 238 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe primary analysis was complete-case.\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -1 mmHg in the control group.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Kenya.\nAfter screening 255 candidates, 228 participants were randomized.\nAllocation assigned 114 participants to the intervention and 114 to usual care.\nThe intervention was a supervised cycling.\nThe comparator was usual care.\nThe primary endpoint visit was at 12 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nSupplement: 222 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Kenya", "randomized_total": "228", "intervention_n": "114", "control_n": "114", "intervention": "supervised cycling", "comparator": "usual care", "duration_weeks": "12", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-8", "control_change": "-1", "funding": null}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Kenya.", "randomized_total": "After screening 255 candidates, 228 participants were randomized.", "intervention_n": "Allocation assigned 114 participants to the intervention and 114 to usual care.", "control_n": "Allocation assigned 114 participants to the intervention and 114 to usual care.", "intervention": "The intervention was a supervised cycling.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 12 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -1 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -8 mmHg in the intervention group and -1 mmHg in the control group.", "funding": ""}}
{"item_id": "SYN-23", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-23. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 246 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe primary analysis was intention-to-treat.\nThe masking description was: outcome assessors masked.\nAt the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -2 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in India.\nAfter screening 263 candidates, 236 participants were randomized.\nAllocation assigned 118 participants to the intervention and 118 to usual care.\nThe intervention was a home exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 16 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nSupplement: 230 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "India", "randomized_total": "236", "intervention_n": "118", "control_n": "118", "intervention": "home exercise", "comparator": "usual care", "duration_weeks": "16", "primary_outcome": "change in systolic blood pressure", "analysis": "intention-to-treat", "blinding": "outcome assessors masked", "intervention_change": "-9", "control_change": "-2", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in India.", "randomized_total": "After screening 263 candidates, 236 participants were randomized.", "intervention_n": "Allocation assigned 118 participants to the intervention and 118 to usual care.", "control_n": "Allocation assigned 118 participants to the intervention and 118 to usual care.", "intervention": "The intervention was a home exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 16 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was intention-to-treat.", "blinding": "The masking description was: outcome assessors masked.", "intervention_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -2 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -9 mmHg in the intervention group and -2 mmHg in the control group.", "funding": "Funding was a public research grant."}}
{"item_id": "SYN-24", "split": "test", "text": "FICTIONAL TRAINING EXCERPT SYN-24. Not a real publication or clinical evidence.\nQuestion: Does exercise added to usual care change systolic blood pressure in adults with essential hypertension?\nBackground: An earlier pilot enrolled 254 people and followed them for 6 weeks. Those values do not describe this trial.\nMethods and results:\nThe masking description was: open label.\nAt the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -3 mmHg in the control group.\nFunding was a public research grant.\nThis was a parallel randomized trial.\nEligible participants were adults with essential hypertension.\nThe study took place in Chile.\nAfter screening 271 candidates, 244 participants were randomized.\nAllocation assigned 122 participants to the intervention and 122 to usual care.\nThe intervention was a group exercise.\nThe comparator was usual care.\nThe primary endpoint visit was at 24 weeks.\nThe prespecified primary outcome was change in systolic blood pressure.\nThe primary analysis was complete-case.\nSupplement: 238 participants completed the endpoint visit. A secondary diastolic pressure outcome changed by -2 mmHg. The next planned follow-up was 52 weeks. Neither is the primary endpoint.\nDiscussion: Extraction of reported values is not an assessment of bias, efficacy, or suitability for patient care.", "gold": {"design": "parallel randomized trial", "population": "adults with essential hypertension", "country": "Chile", "randomized_total": "244", "intervention_n": "122", "control_n": "122", "intervention": "group exercise", "comparator": "usual care", "duration_weeks": "24", "primary_outcome": "change in systolic blood pressure", "analysis": "complete-case", "blinding": "open label", "intervention_change": "-10", "control_change": "-3", "funding": "public research grant"}, "quotes": {"design": "This was a parallel randomized trial.", "population": "Eligible participants were adults with essential hypertension.", "country": "The study took place in Chile.", "randomized_total": "After screening 271 candidates, 244 participants were randomized.", "intervention_n": "Allocation assigned 122 participants to the intervention and 122 to usual care.", "control_n": "Allocation assigned 122 participants to the intervention and 122 to usual care.", "intervention": "The intervention was a group exercise.", "comparator": "The comparator was usual care.", "duration_weeks": "The primary endpoint visit was at 24 weeks.", "primary_outcome": "The prespecified primary outcome was change in systolic blood pressure.", "analysis": "The primary analysis was complete-case.", "blinding": "The masking description was: open label.", "intervention_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -3 mmHg in the control group.", "control_change": "At the primary endpoint, systolic pressure changed by -10 mmHg in the intervention group and -3 mmHg in the control group.", "funding": "Funding was a public research grant."}}